CtIP Antibody

抗体

视网膜母细胞瘤结合蛋白8抗体 | 视网膜母细胞瘤结合蛋白8多克隆抗体 | CtIP抗体 | CtIP多克隆抗体 | RBBP8抗体 | RBBP8多克隆抗体

COM1 antibody | COM1_HUMAN antibody | CtBP interacting protein antibody | CtBP-interacting protein antibody | CtIP antibody | DNA endonuclease RBBP8 antibody | JWDS antibody | RB binding protein 8 endonuclease antibody | RBBP-8 antibody | RBBP8 antibody |

Liquid

Ab098073-10μl

10μl

无载体

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

10mM PBS, 40% Glycerol, 0.05% Sodium azide, pH 7.4.

0.05% Sodium azide

Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations. Post-translational: Acetylated. Deacetylation by SIRT6 upon DNA damage promotes DNA end resection.Hyperphosphorylation upon ionizing radiation results in dissociation from BRCA1. Phosphorylation at Thr-847 by CDK1 is essential for the recruitment to DNA and the DNA repair function. Phosphorylated on Ser-327 as cells enter G2 phase. This phosphorylation is required for binding BRCA1 and for the G2/M DNA damage transition checkpoint control. Ubiquitinated (PubMed:14654780, PubMed:16818604). Ubiquitination at multiple sites by BRCA1 (via its N-terminal RING domain) does not lead to its proteosomal degradation but instead the ubiquitinated RBBP8 binds to chromatin following DNA damage and may play a role in G2/M checkpoint control (PubMed:16818604). Ubiquitinated by RNF138 at its N-terminus (PubMed:26502057).

Fusion protein of human RBBP8.

兔(Rabbit)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

RBBP8

WB: HepG2, HeLa, 231 lysates. IHC: Human thyroid cancer, breast cancer tissue.

150 kDa

Unconjugated

Rabbit IgG

多克隆抗体

Antigen affinity purified

Whole IgG