Cullin 4B/CUL-4B Mouse mAb

抗体

CUL-4B抗体 | CUL4B蛋白抗体

CUL 4Bantibody | CUL-4B antibody | CUL4B antibody | CUL4B_HUMAN antibody | Cullin-4B antibody | DKFZp686F1470 antibody | KIAA0695 antibody | MRXHF2 antibody | MRXSC antibody | SFM2 antibody | SFM2 | MRXSC | CUL-4B | MRXHF2 | MRXS15

Liquid

Ab098185-10μl

10μl

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3

0.02% Sodium azide

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. Post-translational: Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.

Recombinant protein of human CUL4B (AA 1-300).

小鼠(Mouse)

人(Human), 大鼠(Rat), 小鼠(Mouse), 狗(Dog) | 人(Human),大鼠(Rat),小鼠(Mouse),狗(Dog)

CUL4B

WB: HepG2, HeLa, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF7 lysates. IHC: Human pancreas, thyroid, prostate tissues.

150 kDa

Unconjugated

Mouse IgG2b

单克隆抗体

Protein A/G purified

OTI1C4

Whole IgG