Recombinant Dnmt1 Antibody

抗体

DNA甲基转移酶1抗体

AIM | CXXC9 | CXXC9CXXC finger protein 9 | CXXC-type zinc finger protein 9 | DNA (cytosine-5-)-methyltransferase 1 | DNA (cytosine-5)-methyltransferase 1 | DNA methyltransferase 1 | DNA methyltransferase HsaI | DNA MTase HsaI | DNMT | EC 2.1.1.37 | DNMT1

Liquid

Ab100220-10μl

10μl

重组

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

4°C 短期储存（1-2 周）。-20°C下长期保存（24个月）。收货后建议分装。避免冷冻/解冻循环。

10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH7.4

0.02% Sodium azide

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.

A synthetic peptide derived from human DNMT1 (AA 1500-1616)

兔(Rabbit)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

DNMT1

WB: HeLa and Jurkat cell lysates. IHC: Rat spleen, Human lung large cell cancer, Human glioblastoma, Mouse lung tissues.

150 kDa

Unconjugated

Rabbit IgG

重组抗体

kappa

Protein A purified

Whole IgG