DRP1 Mouse mAb

抗体

动力相关蛋白1多克隆抗体 | 动力相关蛋白1抗体 | 动力相关蛋白1单克隆抗体 | DRP1抗体 | DRP1单克隆抗体 | DNM1L抗体 | DNM1L单克隆抗体

DLP1 antibody | dnm1l antibody | DNM1L_HUMAN antibody | Dnm1p/Vps1p-like protein antibody | dnml1 antibody | DRP1 antibody | DVLP antibody | Dymple antibody | Dynamin 1 like antibody | Dynamin family member proline-rich carboxyl-terminal domain less antib

Liquid

Ab100522-10μl

10μl

已验证

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3

0.02% Sodium azide

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport. Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed. Post-translational: Phosphorylation/dephosphorylation events on two sites near the GED domain regulate mitochondrial fission. Phosphorylation on Ser-637 inhibits mitochondrial fissin probably through preventing intramolecular interaction. Dephosphorylated on this site by PPP3CA which promotes mitochondrial fission. Phosphorylation on Ser-616 also promotes mitochondrial fission. Sumoylated on various lysine residues within the B domain. Desumoylated by SENP5 during G2/M transition of mitosis. Appears to be linked to its catalytic activity. S-nitrosylation increases DNM1L dimerization, mitochondrial fission and causes neuronal damage. Ubiquitination by MARCH5 affects mitochondrial morphology.

Recombinant protein of human DNM1L (AA 1-736).

小鼠(Mouse)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

DRP1

WB: HepG2, HeLa, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF7 lysates. IHC: Human kidney, ovary adenocarcinoma, bladder, bladder carcinoma tissues. IF/ICC: COS7 cells.

150 kDa

Unconjugated

Mouse IgG2b | Rabbit IgG

单克隆抗体

Protein A/G purified

OTI3E11

Whole IgG