Recombinant HDAC2 Antibody

抗体

组蛋白去乙酰化酶2抗体 | 组蛋白去乙酰化酶2单克隆抗体 | 组蛋白去乙酰化酶2重组单克隆抗体 | HDAC2抗体 | HDAC2单克隆抗体 | HDAC2重组单克隆抗体

EC 3.5.1.98 | HD2 | HDAC2 | Histone Deacetylase 2 | RPD3 | transcriptional regulator homolog RPD3 | YAF1 | YY1-associated factor 1 | D10Wsu179e antibody | HD 2 antibody | HD2 antibody | HDAC 2 antibody | Hdac2 antibody | HDAC2_HUMAN antibody | OTTHUMP0000

Liquid

Ab107032-10μl

10μl

重组

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。

10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4.

0.02% Sodium azide

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Post-translational: S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching.

A synthetic peptide derived from human HDAC2 (AA 461-488).

兔(Rabbit)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

HDAC2

WB: HeLa, HEK293, MCF7, K562 and NIH/3T3 cell lysates. IHC: Human breast tissue. IF/ICC: HeLa cells.

150 kDa

Unconjugated

Rabbit IgG

重组抗体

kappa

Protein A purified

Whole IgG