HIF3 alpha/IPAS Mouse mAb

抗体

缺氧诱导因子3α/HIF-3α抗体 | HIF3 alpha/IPAS抗体 | HIF3 alpha/IPAS单克隆抗体

HIF3A | IPAS | MOP7 | PASD7 | HIF-3A | bHLHe17 | HIF3-alpha-1 | Basic-helix-loop-helix-PAS protein MOP7 antibody | bHLHe17 antibody | Class E basic helix-loop-helix protein 17 antibody | HIF 3A antibody | HIF 3A4 antibody | HIF-3-alpha antibody | HIF3 alp

Liquid

Ab107519-10μl

10μl

已验证

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存4℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3

0.02% Sodium azide

Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea.

Recombinant protein fragment of human HIF3A produced in E.coli (AA 355-669)

小鼠(Mouse)

人(Human)

HIF3 alpha/IPAS

WB: HEK293T transfected with the pCMV6-ENTRY HIF3A cDNA for 48 hrs, HepG2, HeLa, Jurkat and MCF7 lysates.

150 kDa

Unconjugated

Mouse IgG1

单克隆抗体

Protein G purified

OTI2F7

Whole IgG