Recombinant Interferon alpha/beta receptor 1 Antibody

抗体

Interferon alpha/beta receptor 1抗体 | Interferon alpha/beta receptor 1重组抗体 | 干扰素α/β受体抗体 | 干扰素α/β受体1抗体

Alpha type antiviral protein antibody | Antiviral protein, alpha-type antibody | Antiviral protein, beta-type antibody | AVP antibody | Beta type antiviral protein antibody | CRF2-1 antibody | Cytokine receptor class-II member 1 antibody | Cytokine recept

Liquid

Ab110955-10μl

10μl

重组

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4.

0.02% Sodium azide

Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

A synthetic peptide derived from human Interferon alpha/beta receptor 1 (AA 100-150).

兔(Rabbit)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

Interferon alpha/beta receptor 1

WB: Mouse brain, Rat brain, K562, HEK293 lysates.

150 kDa

Unconjugated

Rabbit IgG

重组抗体

kappa

Protein A purified

Whole IgG