Recombinant JAK2 Antibody

抗体

蛋白质酪氨酸激酶JAK2重组兔单克隆抗体 | 蛋白质酪氨酸激酶JAK2单克隆抗体 | 蛋白质酪氨酸激酶JAK2抗体

Anti-JAK2 antibody | JAK 2 antibody | JAK-2 antibody | JAK2 antibody | JAK2_HUMAN antibody | Janus Activating Kinase 2 antibody | Janus kinase 2 (a protein tyrosine kinase) antibody | Janus kinase 2 antibody | JTK 10 antibody | JTK10 antibody | kinase Jak

Liquid

Ab111455-10μl

10μl

重组

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

4°C 短期储存（1-2 周）。-20°C下长期保存（24个月）。收货后建议分装。避免冷冻/解冻循环。

10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4

0.02% Sodium azide

Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors, which constitutes an initiating step in signaling for many members of the cytokine receptor superfamily including the receptors for growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), granulocyte-macrophage colony-stimulating factor (CSF2), thrombopoietin (THPO) and multiple interleukins. Following stimulation with erythropoietin (EPO) during erythropoiesis, it is autophosphorylated and activated, leading to its association with erythropoietin receptor (EPOR) and tyrosine phosphorylation of residues in the EPOR cytoplasmic domain. Also involved in promoting the localization of EPOR to the plasma membrane. Also acts downstream of some G-protein coupled receptors. Plays a role in the control of body weight (By similarity). Mediates angiotensin-2-induced ARHGEF1 phosphorylation. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.

A synthetic peptide derived from human JAK2 (AA 1100-1132)

兔(Rabbit)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

JAK2

WB: NIH/3T3 and C6 cell lysates. IF/ICC: HeLa, Jurkat cells.

150 kDa

Unconjugated

Rabbit IgG

重组抗体

kappa

Protein A purified

Whole IgG

苏门答腊猩猩(Sumatran orangutan)