NGAL Mouse mAb

抗体

中性粒细胞明胶酶相关脂质运载蛋白抗体 | 中性粒细胞明胶酶相关脂质运载蛋白单克隆抗体 | 中性粒细胞明胶酶相关脂质运载蛋白包被抗体 | NGAL抗体 | NGAL单克隆抗体 | NGAL包被抗体 | LCN2抗体 | LCN2单克隆抗体 | LCN2包被抗体 | Lipocalin 2抗体 | Lipocalin 2单克隆抗体 | Lipocalin 2包被抗体

24p3 antibody | 25 kDa alpha 2 microglobulin related subunit of MMP9 antibody | 25 kDa alpha-2-microglobulin-related subunit of MMP-9 antibody | Alpha 2 microglobulin related protein antibody | HGNC:6526 antibody | HNL antibody | Lcn 2 antibody | Lcn2 ant

Liquid

Ab113226-10μg

10μg

≥90%(SDS-PAGE)

2-8°C储存

冰袋运输

长期储存2-8℃（24个月）；收货后建议分装。

20mM PBS, 0.05% ProClin 300, pH 7.2-7.4

0.05% ProClin 300

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Recombinant NGAL protein.

小鼠(Mouse)

人(Human)

LCN2

150 kDa

Unconjugated

Mouse IgG1

单克隆抗体

kappa

Antigen affinity chromatography

4H11

[Ab113225] NGAL Mouse mAb as Detection antibody in LF, ELISA

Whole IgG