MDM2 Antibody

抗体

双微体2癌基因抗体 | MDM2抗体 | MDM2多抗

ACTFS | HDM2 | HDMX | MDM2 oncogene, E3 ubiquitin protein ligase | MDM2 | ACTFS antibody | Double minute 2 protein antibody | E3 ubiquitin-protein ligase Mdm2 antibody | Hdm 2 antibody | Hdm2 antibody | HDMX antibody | MDM 2 antibody | DM2 antibody | MDM2

Liquid

Ab114718-10μl

10μl

无载体

1.0 mg/mL

-20°C储存,避免反复冻融

超低温冰袋运输

4°C 下运输。在 +4°C 下短期储存（1-2 周）。收货后建议分装。长期储存于 -20°C。避免冷冻/解冻循环。

0.42% Potassium phosphate, 0.87% Sodium chloride, 30% Glycerol, 0.01% Sodium azide, pH7.3

0.01% Sodium azide

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human MDM2.

兔(Rabbit)

人(Human), 猴(Monkey) | 人(Human),猴(Monkey)

MDM2

WB: SK-OV-3 cell lysate. IHC: Human lung cancer tissue. IF/ICC: Jurkat cells.

150 kDa

Unconjugated

Rabbit IgG

多克隆抗体

Immunogen affinity purified

Whole IgG