RBCK1 Mouse mAb

抗体

乙型肝炎病毒相关因子4抗体 | RBCK1 小鼠单克隆抗体 | RBCK1 小鼠单抗 | 乙型肝炎病毒相关因子4抗体 | 乙型肝炎病毒相关因子4单克隆抗体 | RBCK1抗体 | RBCK1单克隆抗体

Chromosome 20 open reading frame 18 antibody | HBV associated factor 4antibody | HBV-associated factor 4 antibody | Heme-oxidized IRP2 ubiquitin ligase 1 antibody | Hepatitis B virus X associated protein 4 antibody | Hepatitis B virus X-associated protein

Liquid

Ab124756-10μl

10μl

无载体

0.5 mg/mL

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

10mM PBS, 30% Glycerol, 0.01% Sodium azide, pH 7.3

0.01% Sodium azide

Acts as an E3 ubiquitin-protein ligase, or as part of an E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteoasome. Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates. LUBAC conjugates linear polyubiquitin to IKBKG at 'Lys-285' and 'Lys-309' and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types. Post-translational: Auto-ubiquitinated. Auto-ubiquitination leads to degradation by the proteasome. Phosphorylated. In vitro, phosphorylation inhibits auto-ubiquitination activity.

Recombinant fusion protein of human RBCK1.

小鼠(Mouse)

人(Human)

RBCK1

WB: Jurkat, HEK293, A375 and A549 cell lysates.

150 kDa

Unconjugated

Mouse IgG1

单克隆抗体

kappa

Protein G purified

K39S7K

Whole IgG