SIRT5 Mouse mAb

抗体

沉默调节蛋白5(SIRT5)单克隆抗体

EC 2.3.1.- | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | NAD dependent deacetylase sirtuin 5antibody | NAD dependent lysine demalonylase and desuccinylase sirtuin 5 mitochondrial antibody | NAD dependent protein deacylase sirtuin 5 mitochond

Liquid

Ab127693-10μl

10μl

已验证

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3

0.02% Sodium azide

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.

Recombinant full length protein of human SIRT5 produced in HEK293.

小鼠(Mouse)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

SIRT5

WB: HEK293T transfected with pCMV6-ENTRY SIRT5 cDNA for 48 hrs, HepG2, HeLa, A549, COS7, PC12, MCF7 lysates. IHC: Human Kidney tissue. IF/ICC: COS7 cells transiently transfected with pCMV6-ENTRY SIRT5. Flow Cytometry: HEK293T cells transfected with pCMV6-

150 kDa

Unconjugated

Mouse IgG1 | Rabbit IgG

单克隆抗体

kappa

Protein G purified

OTI2F10

Whole IgG