Recombinant SMCHD1 Antibody

抗体

SMCHD1抗体 | SMCHD1重组抗体

KIAA0650 | SMC hinge domain containing 1 | SMC hinge domain containing protein 1 | Smchd1 | SMHD1_HUMAN | Structural maintenance of chromosomes flexible hinge domain containing 1 | Structural maintenance of chromosomes flexible hinge domain-containing pro

Liquid

Ab128333-10μl

10μl

重组

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4

0.02% Sodium azide

Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin. Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X. Required to facilitate Xist RNA spreading (By similarity).Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus. Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation. Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks.Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair.

A synthetic peptide derived from human SMCHD1 (AA 1800-2005).

兔(Rabbit)

人(Human)

SMCHD1

WB: U-2 OS cell lysate.

150 kDa

Unconjugated

Rabbit IgG

重组抗体

Protein A purified

Whole IgG