Recombinant SMURF2 Antibody

抗体

Smad蛋白E3泛素连接酶2抗体 | Smad蛋白E3泛素连接酶2单克隆抗体 | Smad蛋白E3泛素连接酶2重组单克隆抗体 | SMURF2抗体 | SMURF2单克隆抗体 | SMURF2重组单克隆抗体

DKFZp686F0270 | E3 ubiquitin ligase SMURF2 | E3 ubiquitin-protein ligase SMURF2 | EC 6.3.2 | EC 6.3.2.- | hSMURF2 | MGC138150 | SMAD specific E3 ubiquitin protein ligase 2 | SMAD ubiquitination regulatory factor 2 | SMAD-specific E3 ubiquitin-protein liga

Liquid

Ab128409-100μl

100μL

重组

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。

10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4

0.02% Sodium azide

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

A synthetic peptide derived from human SMURF 2 (AA 215-280)

兔(Rabbit)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

SMURF2

WB: MDA-MB-231, HeLa, A549, NIH/3T3 and C6 cell lysates.

150 kDa

Unconjugated

Rabbit IgG

重组抗体

kappa

Protein A purified

Whole IgG