STK3/MST-2 Mouse mAb

抗体

丝氨酸/苏氨酸蛋白激酶3抗体 | 丝氨酸/苏氨酸蛋白激酶3单克隆抗体 | STK3抗体 | STK3单克隆抗体 | MST-2抗体 | MST-2单克隆抗体

0610042I06Rik antibody | EC 2.7.11.1 antibody | FLJ90748 antibody | KB 1458E12.1 antibody | Kinase responsive to stress 1 antibody | KRS1 antibody | Mammalian STE20 like protein kinase 2 antibody | Mammalian STE20-like protein kinase 2 antibody | Mammalia

Liquid

Ab129591-10μl

10μl

已验证

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3

0.02% Sodium azide

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1.

Recombinant protein of human STK3 (AA 1-491).

小鼠(Mouse)

人(Human), 大鼠(Rat), 小鼠(Mouse), 狗(Dog), 猴(Monkey) | 人(Human),大鼠(Rat),小鼠(Mouse),狗(Dog),猴(Monkey)

STK3

WB: HeLa, HT29, COS7, Jurkat, MDCK, MCF7, 3T3, Mouse brain, liver, spleen, Human brain, Testis lysates. IHC: Human colon, adenocarcinoma of colon, kidney, carcinoma of kidney, liver, lung, ovary, pancreas, endometrium tissue.

150 kDa

Unconjugated

Mouse IgG2b | Rabbit IgG

单克隆抗体

Protein A/G purified

OTI4G10

Whole IgG