Recombinant TRIM21/SS-A Antibody

抗体

核糖核蛋白自身抗原抗体 | 核糖核蛋白自身抗原单克隆抗体 | 核糖核蛋白自身抗原重组单克隆抗体 | TRIM21抗体 | TRIM21单克隆抗体 | TRIM21重组单克隆抗体 | SS-A抗体 | SS-A单克隆抗体 | SS-A重组单克隆抗体

52 kDa ribonucleoprotein autoantigen Ro/SS-A antibody | 52 kDa Ro protein antibody | 52kD Ro/SSA autoantigen antibody | Autoantigen Ro/SSA, 52-KD antibody | E3 ubiquitin-protein ligase TRIM21 antibody | RING finger protein 81 antibody | RNF81 antibody | R

Liquid

Ab132468-100μl

100μL

重组

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。

50mM Tris-Glycine, 150mM NaCl, 40% Glycerol, 0.05% BSA, 0.01% Sodium azide, pH 7.4

0.01% Sodium aizde

E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.

Recombinant protein of human TRIM21 (AA 1-242)

兔(Rabbit)

人(Human)

TRIM21/SS-A

WB: K562, HeLa, Jurkat, HEK293 and MOLT-4 cell lysates.

150 kDa

Unconjugated

Rabbit IgG

重组抗体

kappa

Protein A purified

Whole IgG