TRPM4 Mouse mAb

抗体

TRPM4抗体 | TRPM4单克隆抗体 | 转化受体电位阳离子通道亚家族M成员4抗体

1110030C19Rik antibody | AW047689 antibody | Calcium-activated non-selective cation channel 1 antibody | FLJ20041 antibody | hTRPM4 antibody | Long transient receptor potential channel 4 antibody | LTrpC-4 antibody | LTrpC4 antibody | Melastatin 4 antibod

Liquid

Ab132713-10μl

10μl

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存4℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3.

0.02% Sodium azide

Calcium-activated selective cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:12842017, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca2+, it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane (PubMed:12015988). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822). Isoform 2. Lacks channel activity.

Recombinant full length protein of human TRPM4 expressed in 293T.

小鼠(Mouse)

人(Human)

TRPM4

WB: HEK293T transfected with pCMV6-ENTRY TRPM4 cDNA for 48 hrs; PC12 lysates. IHC: Human liver, liver carcinoma tissues.

150 kDa

Unconjugated

Mouse IgG1

单克隆抗体

Protein G purified

OTI14C3

Whole IgG