TXNDC/TMX Mouse mAb

抗体

TXNDC/TMX抗体 | TXNDC/TMX单克隆抗体 | TXNDC抗体 | 硫氧还蛋白域蛋白1抗体 | TMX单克隆抗体 | TXNDC单克隆抗体 | TMX抗体

PDIA11 antibody | Protein disulfide isomerase family A | Thioredoxin domain containing 1 antibody | Thioredoxin domain containing antibody | Thioredoxin domain-containing protein 1 antibody | Thioredoxin-related transmembrane protein 1 antibody | TMX anti

Liquid

Ab133078-10μl

10μl

已验证

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存4℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3

0.02% Sodium azide

Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:11152479, PubMed:37648867). Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol (PubMed:37648867). The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (PubMed:37648867). Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds (PubMed:22228764, PubMed:29932915). Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane (PubMed:22228764). Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane (PubMed:29932915). Acts as a negative regulator of platelet aggregation following secretion in the extracellular space (PubMed:30425049). Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals (PubMed:27502484, PubMed:31304984). Regulates endoplasmic reticulum-mitochondria Ca2+ flux (PubMed:27502484).

Recombinant full length protein of human TXNDC/TMX produced in HEK293T cell.

小鼠(Mouse)

人(Human), 猴(Monkey) | 人(Human),猴(Monkey)

TXNDC/TMX

WB: HEK293T transfected with pCMV6-ENTRY TMX1 cDNA for 48 hrs; HepG2, HeLa, A549, COS7, Jurkat, MDCK, MCF7 lysates. IHC: Human ovary adenocarcinoma, prostate carcinoma tissues. IF/ICC: COS7 cells transiently transfected with pCMV6-ENTRY TMX1.

150 kDa

Unconjugated

Mouse IgG1

单克隆抗体

Protein G purified

OTI3H5

Whole IgG