Ozanezumab (anti-RTN4), 网状结构 4 的抗体

抗体

Foocen | Neurite outgrowth inhibitor | Neuroendocrine-specific protein | Neuroendocrine-specific protein C homolog | Nogo protein | NSP | Reticulon-5 | RTN-x

Liquid

Ab170567-100μg

100μg

无动物源

≥95%(SDS-PAGE&SEC-HPLC)

>95%

-80℃储存,避免反复冻融

超低温冰袋运输

在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。

Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0

No

Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.

ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)

CHO supernatant

人(Human)

人(Human)

RTN4

1310680-64-8

150 kDa

Human IgG1

重组抗体

kappa

Protein A purified

Primary antibody

抑制剂

网状结构 4 的抗体

Whole IgG