MOB1B Mouse mAb

抗体

MOB4A蛋白抗体 | MOB4A抗体 | MOB4A蛋白抗体 | MOB1B抗体 | MOB1B单克隆抗体

MATS2 | MOB4A | MOBKL1A | MOB1B | MOB kinase activator 1B | MOB1 antibody | Mob1 homolog 1A | Mob1A | Mob1B | Mps one binder kinase activator-like 1A | MATS2 | MOB4A | MOBKL1A | MOB1B | MOB kinase activator 1B | MOB1 antibody

Liquid

Ab179614-10μl

10μl

已验证

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

4°C 短期储存（1-2 周）。-20°C下长期保存（24个月）。收货后建议分装。避免冷冻/解冻循环。

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3

0.02% Sodium azide

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Recombinant full length protein of human MOBKL1A produced in HEK293T.

小鼠(Mouse)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

MOB1B

WB: HEK293T transfected with the pCMV6-ENTRY MOBKL1A cDNA for 48 hrs, HepG2, HeLa, SVT2, A549, COS7, Jurkat, MDCK, PC12 and MCF7 lysates. IHC: Human prostate carcinoma, prostate, liver and kidney tissues.

150 kDa

Unconjugated

Mouse IgG2a | Rabbit IgG

单克隆抗体

Protein A purified

OTI3G9

Whole IgG