c-Kit Mouse mAb

抗体

原癌基因 | 干细胞因子 | 酪氨酸激酶受体 | 干细胞因子受体 | Anti- c-Kit抗体 | c-Kit小鼠单克隆抗体 | 小鼠抗人c-Kit抗体 | c-Kit抗体 | KIT抗体 | Anti- KIT抗体 | KIT小鼠单克隆抗体 | 小鼠抗人KIT抗体 | Anti- SCFR抗体 | SCFR小鼠单克隆抗体 | 小鼠抗人SCFR抗体 | CD117抗体 | Anti- CD117抗体 | CD117小鼠单克隆抗体 | 小鼠抗人CD117抗体

C Kit antibody | c-Kit antibody | c-Kit Ligand antibody | CD117 antibody | Kit antibody | Kit Ligand antibody | KIT oncogene antibody | KIT proto oncogene receptor tyrosine kinase antibody | KIT_HUMAN antibody | Mast cell growth factor receptor antibody |

Ab183891-10μl

10μl

无动物源

≥95%(SDS-PAGE)

-20°C储存,避免反复冻融

超低温冰袋运输

Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

PBS, pH 7.2

Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

Recombinant protein corresponding to Human c-Kit

小鼠(Mouse)

人(Human)

Human c-Kit

WB: K562, HeLa and Jurkat whole cell lysates IF/ICC: HEL cells

150.0 KDa

Unconjugated

Mouse IgG2b

单克隆抗体

kappa

Protein A purified

AB01/4F12

Whole IgG