ACER2 Antibody

抗体

ACER2抗体 | ACER2多克隆抗体

ASAH3L | ALKCDase2 | 2410116I05Rik | ACER2 | CRG-L1 | maCER2 | PP11646

Ab213089-10μl

10μl

无载体

1.0 mg/mL

-20°C储存,避免反复冻融

超低温冰袋运输

Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

0.42% Potassium phosphate, 0.87% Sodium chloride, 30% Glycerol, 0.01% Sodium azide, pH 7.3

0.01% Sodium azide

Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:16940153, PubMed:18945876, PubMed:20089856, PubMed:20207939). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20207939). Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (PubMed:16940153, PubMed:18945876, PubMed:20089856, PubMed:20207939). Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates (PubMed:20089856). Also hydrolyzes dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (By similarity). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate (PubMed:16940153, PubMed:26943039, PubMed:28294157, PubMed:29229990). As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage (PubMed:26943039, PubMed:28294157, PubMed:29229990). Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (PubMed:18945876).

A synthetic peptide derived from human ACER2

兔(Rabbit)

人(Human), 大鼠(Rat), 小鼠(Mouse), 猴(Monkey) | 人(Human),大鼠(Rat),小鼠(Mouse),猴(Monkey)

ACER2

WB: Mouse testis, Rat kidney, HeLa, Hep G2, MCF7 and A549 lysates.

150 kDa

Unconjugated

Rabbit IgG

多克隆抗体

Immunogen affinity purified

Whole IgG