DNA PKcs Mouse mAb

抗体

DNA依赖性蛋白激酶 | DNA 依赖性蛋白激酶催化亚基 | PRKDC小鼠单克隆抗体 | DNA-PKcs抗体 | PRKDC抗体

DNA dependent protein kinase catalytic subunit antibody | DNA PK catalytic subunit antibody | DNA-dependent protein kinase catalytic subunit antibody | DNA-PK catalytic subunit antibody | DNA-PKcs antibody | DNAPK antibody | DNAPK catalytic subunit antibo

Ab214908-10μl

10μl

无载体

≥95%(SDS-PAGE)

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融.

PBS, pH 7.4

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D.

Recombinant protein corresponding to human DNA PKcs

小鼠(Mouse)

人(Human)

Human DNA PKcs

Flow Cytometry: HepG2 cells

150.0 KDa

Unconjugated

Mouse IgG1

单克隆抗体

kappa

Protein A purified

AB01/3E5

Whole IgG