Recombinant TCR γ/δ Antibody (FITC)

抗体

Ab216133-10T

10T

已验证

5 μL/test

2-8°C储存,避光,禁止冷冻

冰袋运输

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300.

0.05% Proclin300

Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair. Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells. Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements.

小鼠(Mouse)

人(Human)

Human TCR γ/δ

Flow Cytometry: Human peripheral blood lymphocytes

FITC

Mouse IgG1

重组抗体

kappa

Protein A purified

P22D01

Blue Laser(488nm)

517nm

Ex:498nm;Em:517nm

Whole IgG