Recombinant CD5 Antibody

抗体

分化簇5 | 淋巴细胞表面抗原5 | CD5单克隆抗体 | CD5抗体

CD 5 antibody | CD5 antibody | CD5 antigen (p56 62) antibody | CD5 antigen antibody | CD5 molecule antibody | CD5_HUMAN antibody | LEU1 antibody | LyA antibody | Lymphocyte antigen T1/Leu-1 antibody | OTTHUMP00000236973 antibody | T-cell surface glycoprot

Ab222902-10μg

10μg

无动物源

≥95%(SDS-PAGE)

-20°C储存,避免反复冻融

超低温冰袋运输

Store at 2-8℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

PBS, pH 7.4

Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (By similarity). Modulates B-cell biology through ERK1/2 activation in a Ca2+-dependent pathway via the non-selective Ca2+ channel TRPC1, leading to IL-10 production (By similarity).

Mouse Thymus / Spleen

大鼠(Rat)

小鼠(Mouse)

Mouse CD5

Flow Cytometry: C57BL/6 mouse splenocytes

150 kDa

Unconjugated

Rat IgG2a

重组抗体

kappa

Protein A purified

P27B11

Whole IgG