Recombinant CD27 Antibody

抗体

肿瘤坏死因子受体超家族成员7 | CD27抗体 | CD27/TNFRSF7单克隆抗体

CD 27 antibody | CD27 antibody | CD27 antigen antibody | CD27 molecule antibody | CD27_HUMAN antibody | CD27L receptor antibody | LPFS2 antibody | MGC20393 antibody | OTTHUMP00000238557 antibody | S152 antibody | T cell activation antigen CD27 antibody |

Ab222917-10μg

10μg

无动物源

≥95%(SDS-PAGE)

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融.

PBS, pH 8.0

Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed:28011863). Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis (By similarity). Negatively regulates the function of Th2 lymphocytes in the adipose tissue (By similarity).

Human Thymocytes

小鼠(Mouse)

人(Human)

Human CD27

Flow Cytometry: Human peripheral blood lymphocytes

150 kDa

Unconjugated

Mouse IgG1

重组抗体

kappa

Protein A purified

P08D01

Whole IgG