苯甲酸双环霉素是一种极性代谢产物，于1972年首次从札幌链霉菌中分离出来，具有抗革兰氏阴性细菌的活性。在链霉菌的代谢产物中，双环霉素苯甲酸酯的选择性革兰氏阴性谱很罕见，为了克服其体内吸收差的问题，苯甲酸酯是通过与暴露程度更高的伯醇反应制得的。 Bicyclomycin benzoate is a polar metabolite first isolated from Streptomyces sapporonensis in 1972 with activity against Gram negative bacteria. The selective Gram negative profile of Bicyclomycin benzoate is rare among Streptomyces metabolites, and in an effort to overcome its poor in vivo absorption, the benzoate ester was prepared by reaction with the more exposed primary alcohol.