BMS-1166是新型有效的PD-1/PD-L1相互作用抑制剂，IC50为1.4 nM。 Information BMS-1166 BMS-1166 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 interaction with an IC50 of 1.4 nM. Targets PD-1/PD-L1 interaction 1.4 nM In vitro BMS-1166 presents low toxicity towards tested cell lines and blocks the interaction of soluble PD-L1 with the cell surface-expressed PD-1. BMS-1166 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.