BAMB-4

BAMB-4

B647905-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

BAMB-4 (ITPKA-IN-C14) is a specific and membrane-permeable ITPKA inhibitor. BAMB-4 has high stability and membrane permeability and against the inositol-1,4,5-trisphosphate (InsP3) kinase activity of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA) with an IC 50 value of 20 μM. BAMB-4 can be used for the research of metastasis of lung cancer In Vitro BAMB-4 (0.3-40 μM) has ITPKA inhibiton effect with an IC 50 value of 37 μM. BAMB-4 (40 μM) inhibits InsP3 kinase activity with an IC 50 value of 20 μM. BAMB-4 (100 μM, overnight) has high specificity and the high cellular uptake. BAMP-4 (0, 10, 20 and 40 μM) shows increased K m and decreased V max. BAMP-4 (0-30 μM) is a mixed type inhibitor with respect to ATP and InsP3 and does not only affect binding of ATP but also binding of InsP3，which affects turnover of two substrate exhibit a higher inhibition specifcity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 37 μM (ITPKA),20 μM (InsP3 kinase)

BAMB-4（ITPKA-IN-C14）是一种特异性、膜渗透性 ITPKA 抑制剂。 BAMB-4 具有很高的稳定性和膜渗透性，能抑制肌醇-1,4,5-三磷酸激酶 A（ITPKA）的肌醇-1,4,5-三磷酸激酶（InsP3）活性。

891025-25-5

C15H12N2O2

252.27 g/mol

8087347

CC1=CC=C(C=C1)C(=O)NC2=NOC3=CC=CC=C32

N-(1,2-benzoxazol-3-yl)-4-methylbenzamide

1S/C15H12N2O2/c1-10-6-8-11(9-7-10)15(18)16-14-12-4-2-3-5-13(12)19-17-14/h2-9H,1H3,(H,16,17,18)

IEPCQLHHUYRTEY-UHFFFAOYSA-N

CC1=CC=C(C=C1)C(=O)NC2=NOC3=CC=CC=C32

8087347

DMSO : ≥ 40 mg/mL (158.56 mM)

1

3

2

252.09 Da

252.09 Da

55.100 Ų

19

0

326.000

0

1

3.200