Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis In Vitro Bax activator-1 (20-80 μM; 48 hours) induces Bax-dependent tumor cell apoptosis in a dose-dependent fashion. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: Lewis Lung Carcinoma tumor cells, human non-small cell lung carcinoma A549 cells, human pancreatic carcinoma Panc-1 cells Concentration: 20 μM, 40 μM , 60 μM , 80 μM Incubation Time: 48 hours Result: Induced apoptotic cell death in the murine Lewis Lung Carcinoma (LLC), human non-small cell lung carcinoma A549 cells and PANC-1 human pancreatic carcinoma cells in a dose-dependent fashion. In Vivo Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells) Dosage: 40 mg/kg Administration: Given i.p., each day for 13 days Result: Exhibited anti-tumor activity as a single-agent. Form:Solid IC50& Target:Bax