BRD5648

BRD5648

B649456-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

BRD5648 ((R)-BRD0705) is a negative control of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC 50 of 66 nM and a K d of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC 50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML). In Vitro BRD5648, the inactive enantiomer of BRD0705, does not induce changes in enzyme phosphorylation or total β-catenin protein stabilization. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

BRD5648 （(R)-BRD0705）是 BRD0705 的阴性对照品。BRD0705 是一种强效、具有旁路选择性和口服活性的 GSK3α 抑制剂，其 IC 50 为 66 nM，K d 为 4.8 μM。与 GSK3β 相比，BRD0705 对 GSK3α 的选择性更高（8 倍）（IC 50 为 5.8 μM）。

2056261-42-6

C20H23N3O

321.42 g/mol

136980414

(4R)-4-ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one

1S/C20H23N3O/c1-4-20(13-8-6-5-7-9-13)14-12-21-23-18(14)22-15-10-19(2,3)11-16(24)17(15)20/h5-9,12H,4,10-11H2,1-3H3,(H2,21,22,23)/t20-/m1/s1

NCKLQXXBRWCYMA-HXUWFJFHSA-N

CCC1(C2=C(NC3=C1C(=O)CC(C3)(C)C)NN=C2)C4=CC=CC=C4

136980414

DMSO : 300 mg/mL (933.36 mM; Need ultrasonic)