BF 227

BF 227

B654479-1ml

1ml

10mM in DMSO

充氩,-80℃储存

超低温冰袋运输

BF 227 is a candidate for an amyloid imaging probe for PET, with a K i of 4.3 nM for Aβ1-42 fibrils . In Vitro BF-227 has a high binding affinity for Aβ1-42 fibrils. The K i value for Aβ1-42 fibrils in competitive binding assay using [ 125 I]BF-180 is 4.3±1.3 nM in BF-227 (K d value of [ 125 I]BF-180: 10.8±1.5 nM). [ 11 C]BF-227 is a PET tracer. The AUC for BF-227 (0.994) is much higher than that for FDG (0.839), indicating that BF-227 is more sensitive as well as more specific than FDG in diagnosing AD. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Ki: 4.3 nM (Aβ1-42)

BF 227 是 PET 淀粉样蛋白成像探针的候选者，对 Aβ1-42 纤维的 K i 为 4.3 nM。

845647-80-5(DMSO)

C16H16FN3O2S

333.38 g/mol

CN(C)C1=NC=C(S1)C=CC2=NC3=C(O2)C=C(C=C3)OCCF