BAN ORL 24

BAN ORL 24

B654527-1ml

1ml

10mM in DMSO

避光,充氩,-80℃储存

超低温冰袋运输

BAN ORL 24 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 has antagonistic effect for nociceptin (NOP) receptor with K I value of 0.24 nM in CHO cell. BAN ORL 24 can be used for the research of cancer and analgesic In Vitro BAN ORL 24 has antagonist for NOR and MOR (opioid receptor subtype) with IC 50 values of 50 μM and 0.224 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo BAN ORL 24 (10 mg/kg; i.v.) attenuates the duration of BPRIM97 thermal antinociception. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 miceDosage: 10 mg/kg Administration: 10 mg/kg; i.v. Result: Caused inhibition of BPRIM97-induced antinociception at 90-min postinjection. Did not attenuate BPR1M97-induced antinociception in the tail-clip test after 30 min. IC50& Target:Ki: 0.24 nM (NOP in CHO cell),IC50: 50 μM (NOR),0.224 μM (MOR)

BAN ORL 24 是一种痛觉素/孤儿素 FQ（N/OFQ）肽受体（NOP）拮抗剂。BAN ORL 24 对痛觉素（NOP）受体具有拮抗作用，在 CHO 细胞中的 K I 值为 0.24 nM。BAN ORL 24 可用于癌症和镇痛研究。

1401463-54-4(DMSO)

C27H35N3O2.2HCl

506.51 g/mol

C1CC(N(C1)CC2=CC=CC=C2)C(=O)NCCCN3CCC4(CC3)C5=CC=CC=C5CO4.Cl.Cl