Barbadin

摧毁它

Barbadin

B655163-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC 50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-Vasotocin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis In Vitro Barbadin (4 h) treatment reduces cell viability and induces apoptosis. Barbadin (2 h) treatment arrests breast cancer cells in G0/G1 phase. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: MDA MB-231 cells Concentration: Incubation Time: 4 hours Result: Exhibited morphological characteristics of apoptosis including shrinkage, rounding and detachment, the percent of cell viability was reduced to 69.1% and apoptosis was developed in 29.9% of cells starved with EBSS (Earle’s balanced salt solution). Cell Cycle AnalysisCell Line: MDA MB-231 cells Concentration: Incubation Time: 2 hours Result: Arrested 63.7% of cells in G0/G1 phase. IC50& Target:IC50: 19.1 μM (β-arrestin1),15.6 μM (β-arrestin2)

Barbadin 是一种新型的选择性 β-arrestin/β2-adaptin 相互作用抑制剂，对 β-arrestin1 和 β-arrestin2 的 IC 50 值分别为 19.1u2009μM 和 15.6u2009μM。Barbadin可阻断激动剂促进的β2-肾上腺素能、V2-血管紧张素原型的内吞作用。

356568-70-2(DMSO)

C19H15N3OS

333.41 g/mol

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