(Rac)-BRD0705

(Rac)-BRD0705

B655690-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC 50 of 66 nM and a K d of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC 50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML).

(Rac)-BRD0705 是 BRD0705 活性较低的外消旋体。BRD0705 是一种强效、具有对位表选择性和口服活性的 GSK3α 抑制剂，其 IC 50 为 66 nM，K d 为 4.8 μM。与 GSK3β 相比，BRD0705 对 GSK3α 的选择性提高了 8 倍（IC 50 为 515 nm）。

1597440-03-3(DMSO)

C20H23N3O

321.42 g/mol

CCC1(C2=C(NC3=C1C(=O)CC(C3)(C)C)NN=C2)C4=CC=CC=C4