Bomedemstat dihydrochloride

盐酸波美司他

Bomedemstat dihydrochloride

B658800-5mg

5mg

≥99%

-20°C储存,干燥

超低温冰袋运输

Bomedemstat (IMG-7289) dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 ( LSD1 ) inhibitor. Bomedemstat dihydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat dihydrochloride s Appearance:Solid IC50& Target:KDM1/LSD1 In Vitro:Bomedemstat dihydrochloride selectively inhibits proliferation and induces apoptosis of Jak2 V617F cells by concomitantly increasing expression and methylation of p53. Bomedemstat (50 nM-1 μM; 96 h; SET-2 cells) dihydrochloride enhances survival, ind In Vivo:Bomedemstat (oral gavage; 45mg/kg; once daily; 56 d) dihydrochloride normalizes or improves blood cell counts, reduces spleen volumes, restores normal splenic architecture, and reduces bone marrow fibrosis. MCE has not independently confirmed the ac Biological Activity:Bomedemstat (IMG-7289) dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 ( LSD1 ) inhibitor. Bomedemstat dihydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat dihydrochloride s

C28H36Cl2FN7O2

592.54 g/mol

O=C(N1CCN(CC1)C)[C@@H](NC(C2=CC=C(N3C=CN=N3)C=C2)=O)CCCN[C@H]4[C@@](C5=CC=C(C=C5)F)([H])C4.[H]Cl.[H]Cl