BIIE-0246 hydrochloride

BIIE-0246 盐酸盐

BIIE-0246 hydrochloride

B658856-1mg

1mg

≥99%

2-8°C储存,干燥

冰袋运输

BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC 50 value of 15 nM for rat [ 125 I]PYY 3-36 . BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAP Appearance:Solid In Vitro:BIIE-0246 hydrochloride (1 µM; 24 h) decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated (10, 100 ng/mL) in mouse podocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. We In Vivo:BIIE-0246 hydrochloride (1.3mg/kg; I.p.; daily for 2 or 4.5 weeks) prevents diet-induced obesity in OE-NPYDβH mice, but enhances obesity in WT Mice. BIIE-0246 hydrochloride (10 µg/day; i.p.; daily for 14 days) reduces albuminuria in ADR (adriamycin) Biological Activity:BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC 50 value of 15 nM for rat [ 125 I]PYY 3-36 . BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAP

C49H57N11O6.xHCl

O=C(N[C@H](C(NCCN1C(N(C2=CC=CC=C2)N(C3=CC=CC=C3)C1=O)=O)=O)CCCNC(N)=N)CC4(CC(N5CCN(C(C6=CC=CC=C67)C8=CC=CC=C8NC7=O)CC5)=O)CCCC4.[H]Cl.[x]

DMSO : 40 mg/mL (Need ultrasonic and warming)