BIO5192 hydrate

BIO5192 水合物

BIO5192 hydrate

B661664-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor ( K d IC50& Target:α4β1 1.8 nM (IC 50 ) α9β1 138 nM (IC 50 ) α2β1 1053 nM (IC 50 ) α4β7 >500 nM (IC 50 ) In Vivo:The combination of BIO5192 hydrate (1mg/kg; i.v.) and Plerixafor (5mg/kg; s.c.) exert an additive effect on progenitor mobilization. BIO5192 hydrate (30mg/kg; s.c; bid; during days 5 through 14) delays paralysis associated with EAE (experimental a Biological Activity:BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor ( K d

C38H46Cl2N6O8S.1/2H2O

826.79 g/mol

O=[S](N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CCNC([C@H](CC(C)C)N(C)C(CC(C=C2)=CC=C2NC(NC(C=CC=C3)=C3C)=O)=O)=O)=O)(C4=CC(Cl)=CC(Cl)=C4)=O.O.[1/2]