二十碳三烯酸（5Z，11Z，14Z）是一种多不饱和脂肪酸，存在于各种天然资源中，包括海生松（Pinus pinaster）种子油（MPSO），裸子植物的叶子和种子以及淡水腹足动物。在表达人ApoA1的转基因小鼠中，含MPSO的饮食降低了高密度脂蛋白和ApoA1的水平。发现MPSO可以降低体外胆固醇流出。当局部使用5Z，11Z，14Z-二十碳三烯酸甲酯时，可能会通过从磷脂库中置换花生四烯酸并减少下游的炎症产物（例如前列腺素E2和白三烯）来减少炎症过程。 Eicosatrienoic Acid (5Z,11Z,14Z) is a polyunsaturated fatty acid found in various natural sources including maritime pine (Pinus pinaster) seed oil (MPSO), gymnospermae leaves and seeds, and freshwater gastropods. A diet containing MPSO lowered high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro. 5Z,11Z,14Z-Eicosatrienoic acid methyl ester, when topically applied, diminishes inflammatory processes, potentially by displacing arachidonic acid from phospholipid pools and reducing downstream inflammatory products such as prostaglandin E2 and leukotrienes.