8（S）-HETE是嗜中性粒细胞的多不饱和脂肪酸趋化剂，是合成类二十烷酸家族（称为白三烯）的中间体。已经观察到该化合物在人类嗜中性粒细胞，佛波酯处理的小鼠表皮中以及通过肝微粒体细胞色素P-4503是生物合成的。已经观察到8（S）-HETE调节大鼠角膜中的上皮细胞迁移。该化合物还被认为是花生四烯酸在角膜伤口愈合中的关键成分。有证据表明8（S）-HETE激活PPARα和PKC。 8(S)-HETE is a polyunsaturated fatty acid chemotactic for neutrophils and an intermediate in the synthesis of the family of eicosanoids known as leukotrienes. The compound has been observed to be biosynthesized in human neutrophils, phorbol ester-treated mouse epidermis and by hepatic microsomal cytochrome P-4503. 8(S)-HETE has been observed to regulate epithelial cell migration in the rat cornea. The compound has also been recognized as the key component of arachidonic acid in corneal wound healing. Evidence demonstrates 8(S)-HETE activates PPARα and PKC.