在10-樟脑磺酸（CSA）存在下，通过与2,3-二醇反应，2-溴-1,1-二甲氧基乙烷（溴乙醛二甲基乙缩醛）可用于合成2,3-O-10-乙缩醛。 2-Bromo-1,1-dimethoxyethane (Bromoacetaldehyde dimethyl acetal) was used in the synthesis of 2,3-O-acetal via reaction with 2,3-diol in the presence of 10-camphorsulphonic acid (CSA). 2-bromo-1,1-dimethoxyethane was used to react with 4-hydroxylbenzaldehyde, and finally aldehyde substituted prodrug was generated by TFA-mediated deacetalization.