Reactant involved in studies of biologically active molecules including: 1.Discovery of indole inhibitors of MMP-13 for treatment of arthritic diseases. 2.Synthesis of indolyl ethanones as indoleamine 2,3-dioxygenase inhibitors. 3. cis-Diaminocyclohexane derivatives prepared for use as factor Xa inhibitors. 4.Synthesis of tubulin polymerization inhibitors and cancer cell growth inhibitors. 5.Preparation of dual PPARγ/δ agonists. 6.Synthesis of chemical probes to examine the role of hFPRL1 receptor in inflammation.