Reactant for preparation of: · Pyrrolo[2,3-d]pyrimidin-4-ones as corticotropin-releasing factor 1 receptor antagonists with a carbonyl-based hydrogen bonding acceptor · Biaryl pyrazole carboxamides as sodium channel blockers for treatment of neuropathic pain · Biphenylketones as dual modulators of inflammation and bone loss · (Biphenylyl)pyrazolecarboxamides and their voltage-gated sodium channel Nav1.7 blocking structure-activity relationship · N-hydroxyalkyl biphenylsulfonamides as inhibitors of bone resorption · 1,3,6,8a-tetraazaacenaphthylene derivatives and study of their activity as corticotropin-releasing factor-1 antagonists · Blue luminescent iridium phenylpyridine complexes