CMS-121

小分子

4-[4-(Cyclopentyloxy)quinolin-2-yl]benzene-1,2-diol | BW9P9F8JEY | HY-135981 | AKOS040741561 | EX-A4377 | UNII-BW9P9F8JEY | MFCD22192465 | SCHEMBL14697212 | 4-(4-cyclopentyloxyquinolin-2-yl)benzene-1,2-diol | 4-(4-(Cyclopentyloxy)-2-quinolinyl)-1,2-benzen

CMS-121

C646315-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC 50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities In Vitro CMS-121 (1 µM; 4 hours; HT22 cells) treatment increases the phosphorylation of ACC1 at serine 79. CMS-121 can increase acetyl-CoA in cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HT22 cells Concentration: 1 µM Incubation Time: 4 hours Result: Increases the phosphorylation of ACC1 at serine 79. In Vivo CMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female SAMP8 mice (9 months old) Dosage: ~20 mg/kg/day Administration: Oral administration; daily; for 4 months Result: Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain. Form:Solid IC50& Target:Acetyl-CoA carboxylase 1 (ACC1)

CMS-121 是一种喹诺酮衍生物，也是一种口服活性乙酰-CoA 羧化酶 1 (ACC1) 抑制剂。CMS-121 可保护 HT22 细胞免受缺血和氧化损伤，其 EC 50 值分别为 7 nM 和 200 nM。CMS-121 具有很强的神经保护和抗氧化作用。

1353224-53-9

C20H19NO3

321.37 g/mol

135741221

C1CCC(C1)OC2=CC(=NC3=CC=CC=C32)C4=CC(=C(C=C4)O)O

4-(4-cyclopentyloxyquinolin-2-yl)benzene-1,2-diol

1S/C20H19NO3/c22-18-10-9-13(11-19(18)23)17-12-20(24-14-5-1-2-6-14)15-7-3-4-8-16(15)21-17/h3-4,7-12,14,22-23H,1-2,5-6H2

OMHNVUCFPJJLKD-UHFFFAOYSA-N

C1CCC(C1)OC2=CC(=NC3=CC=CC=C32)C4=CC(=C(C=C4)O)O

135741221

1353224-53-9

DMSO : 50 mg/mL (155.58 mM; Need ultrasonic)

2

4

3

321.136 Da

321.136 Da

62.600 Ų

24

0

412

0

1

4.4