Chroman 1

小分子

(3S)-N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-3,4-二氢-6-甲氧基-2H-1-苯并吡喃-3-甲酰胺 | 色满 1

ROCK-II inhibitor | (3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide

Chroman 1

C646731-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 ( IC 50 =1 pM) than ROCK1 ( IC 50 =52 pM). Chroman 1 also has inhibitory activity against MRCK , with an IC 50 of 150 nM In Vitro Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 0-12 h or 24 h Result: Reduced the number of apoptotic cells, reduced caspase-3/7 activation. Western Blot AnalysisCell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 24 h Result: Partially inhibited caspase-3 activation. Form:Solid IC50& Target:ROCK2|1 pM (IC|50|)|ROCK1|52 pM (IC|50|)|MRCK|150 nM (IC|50|)

Chroman 1 是一种高效、选择性的 ROCK 抑制剂。Chroman 1 对 ROCK2 的抑制作用（IC 50 =1 pM）强于 ROCK1（IC 50 =52 pM）。Chroman 1 对 MRCK 也有抑制活性，IC 50 为 150 nM。

1273579-40-0

C24H28N4O4

436.50 g/mol

66577033

CN(C)CCOC1=C(C=CC(=C1)C2=CNN=C2)NC(=O)[C@H]3CC4=C(C=CC(=C4)OC)OC3

CN(C)CCOC1=C(C=CC(=C1)C2=CNN=C2)NC(=O)[C@H]3CC4=C(C=CC(=C4)OC)OC3

66577033

DMSO : ≥ 50 mg/mL (114.55 mM)

2

6

8

436.211 Da

436.211 Da

88.700 Ų

32

0

607.000

0

1

2.700