CDK12-IN-3

CDK12-IN-3

C647924-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC 50 of 491 nM in enzymatic assay. In Vitro CDK12-IN-3 is a highly selective CDK12 inhibitor. CDK12-IN-3 (0.1 μM) shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells.. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CDK12 491 nM (IC 50 )

CDK12-IN-3 是一种强效、选择性 CDK12 抑制剂，在酶促实验中的 IC 50 为 491 nM。

2220184-50-7

C23H28F2N8O

470.52 g/mol

134691746

CC(C)N1C=NC2=C(N=C(N=C21)N3CCCC[C@H]3CCO)NCC4=NC5=C(N4)C=CC(=C5F)F

2-[(2S)-1-[6-[(4,5-difluoro-1H-benzimidazol-2-yl)methylamino]-9-propan-2-ylpurin-2-yl]piperidin-2-yl]ethanol

1S/C23H28F2N8O/c1-13(2)33-12-27-20-21(26-11-17-28-16-7-6-15(24)18(25)19(16)29-17)30-23(31-22(20)33)32-9-4-3-5-14(32)8-10-34/h6-7,12-14,34H,3-5,8-11H2,1-2H3,(H,28,29)(H,26,30,31)/t14-/m0/s1

KULPPFCRBINTBS-AWEZNQCLSA-N

CC(C)N1C=NC2=C(N=C(N=C21)N3CCCCC3CCO)NCC4=NC5=C(N4)C=CC(=C5F)F

DMSO : 250 mg/mL (531.33 mM; Need ultrasonic)

62165380