CDE-096

CDE-096

C649438-5mg

5mg

≥98%

2-8°C储存,避光,干燥

冰袋运输

CDE-096 is a potent inhibitor of PAI-1. CDE-096 prevents PAI-1 from inactivating tPA and uPA with similar potency ( IC 50 =30 and 25 nM, respectively) and is active against glycosylated PAI-1 , as well as PAI-1 derived from several species (IC 50 =19, 22 and 18 nM for murine, rat, and Porcine PAI-1 , respectively). In Vitro CDE-096 is active against both free PAI-1 and vitronectin-bound PAI-1. CDE-096 binds to PAI-1 with nanomolar affinity and induces conformational changes that prevent binding to both proteases and vitronectin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

CDE-096 是 PAI-1 的强效抑制剂。CDE-096 以相似的效力阻止 PAI-1 使 tPA 和 uPA 失活（IC 50 =30 和 25 nM），并对糖基化的 PAI-1 以及来自多个物种的 PAI-1 有活性（IC 50 =19、22、25 nM）。

1228357-04-7

C25H20F3NO12

583.42 g/mol

59350299

C1=CC(=CC(=C1)OC(=O)NCC(COC(=O)C2=CC(=C(C(=C2)O)O)O)OC(=O)C3=CC(=C(C(=C3)O)O)O)C(F)(F)F

[3-[[3-(trifluoromethyl)phenoxy]carbonylamino]-2-(3,4,5-trihydroxybenzoyl)oxypropyl] 3,4,5-trihydroxybenzoate

1S/C25H20F3NO12/c26-25(27,28)13-2-1-3-14(8-13)41-24(38)29-9-15(40-23(37)12-6-18(32)21(35)19(33)7-12)10-39-22(36)11-4-16(30)20(34)17(31)5-11/h1-8,15,30-35H,9-10H2,(H,29,38)

OXWKLJPAKUDPJY-UHFFFAOYSA-N

C1=CC(=CC(=C1)OC(=O)NCC(COC(=O)C2=CC(=C(C(=C2)O)O)O)OC(=O)C3=CC(=C(C(=C3)O)O)O)C(F)(F)F

59350299

DMSO : 100 mg/mL (171.40 mM; Need ultrasonic)