CDK8-IN-1

小分子

CDK8-IN-1

C649452-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC 50 of 3 nM. In Vivo CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The t max is 0.25 h by PO. The mean values of C max are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CDK8 3 nM (IC 50 )

CDK8-IN-1 是一种强效、选择性 CDK8 抑制剂，其 IC 50 为 3 nM。

1629633-48-2

C11H8F3N3O

255.20 g/mol

86274989

C1=CN=CC=C1C2=CNC(=C2C(F)(F)F)C(=O)N

4-pyridin-4-yl-3-(trifluoromethyl)-1H-pyrrole-2-carboxamide

1S/C11H8F3N3O/c12-11(13,14)8-7(5-17-9(8)10(15)18)6-1-3-16-4-2-6/h1-5,17H,(H2,15,18)

RKTPHHQXNCHBCF-UHFFFAOYSA-N

C1=CN=CC=C1C2=CNC(=C2C(F)(F)F)C(=O)N

86274989

DMSO : 100 mg/mL (391.85 mM; Need ultrasonic)

2

5

2

255.062 Da

255.062 Da

71.800 Ų

18

0

315

0

1

1.4