CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier In Vivo CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Hypothyroid Wistar rats Dosage: 0.04, 0.8, 2.5, and 5.0 nmol/g Administration: Ip Result: Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective. Form:Solid IC50& Target:TRα