Celgosivir hydrochloride

小分子

盐酸西戈西韦

Celgosivir hydrochloride

C649960-5mg

5mg

≥98%

2-8°C储存,干燥

冰袋运输

Celgosivir hydrochloride (MBI 3253 hydrochloride; MDL 28574 hydrochloride; MX3253 hydrochloride) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC 50 of 1.27 μM in in vitro assay. In Vitro Celgosivir is more effective (IC 50 =20 μM) than the parent molecule (IC 50 =254 μM) at causing the accumulation of glucosylated oligosaccharides in HIV-infected cells by inhibition of glycoprotein processing. Celgosivir exhibits potent antiviral activity against HIV-1 with an IC 50 of 2.0±2.3 μM. Bovine viral diarrhoea virus (BVDV) is a closely related virus of hepatitis C virus (HCV). Celgosivir inhibits BVDV with IC 50 values of 16 and 47 μM in plaque assay and cytopathic effect assay, respectively. Celgosivir inhibits DENV2 replication with an EC 50 of 0.2 μM. The EC 50 values against DENV1, 3 and 4 are less than 0.7 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Celgosivir fully protects AG129 mice from lethal infection with a mouse adapted dengue virus at a dose of 50 mg/kg twice daily (BID) for 5 days and is effective even after 48 h delayed treatment. The protection by celgosivir is dose- and schedule-dependent and that a twice-a-day regimen of 50, 25 or 10 mg/kg is more protective than a single daily dose of 100 mg/kg. Pharmacokinetics studies of celgosivir in mice shows that it rapidly metabolizes to castanospermine. During primary infection with a mouse-adapted DENV strain S221, mice shows increased viremia on day 3, yet 80% survived day 10 with virus completely cleared by day 8. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 1.27 μM (α-glucosidase I)

Celgosivir hydrochloride（MBI 3253 hydrochloride；MDL 28574 hydrochloride；MX3253 hydrochloride）是一种α-葡萄糖苷酶 I 抑制剂；对牛病毒性腹泻病毒（BVDV）有抑制作用，体外检测的 IC 50 为 1.27 μM。

141117-12-6

C12H22ClNO5

295.76 g/mol

3033824

CCCC(=O)O[C@H]1CN2CC[C@@H]([C@@H]2[C@H]([C@@H]1O)O)O.Cl

CCCC(=O)O[C@H]1CN2CC[C@@H]([C@@H]2[C@H]([C@@H]1O)O)O.Cl

3033824

H2O : ≥ 100 mg/mL (338.11 mM) DMSO : 100 mg/mL (338.11 mM; Need ultrasonic)

4

6

4

295.119 Da

295.119 Da

90.200 Ų

19

0

311

0

2